Study Shows Less Insulin Prolongs Life 18%
Friday, July 20th, 2007 by Bob Maloney at 3:16 PM EDTResearchers reported today in the journal Science the results of an insulin study with mice. “This study provides a new explanation of why it’s good to exercise and not eat too much,” said Dr. Morris White, a Howard Hughes Medical Institute investigator at Children’s Hospital in Boston who led the study.
The researchers created mice whose brains were less sensitive to insulin, the hormone that regulates glucose. The genetic engineering mimicked the effects of less insulin in the brain, as occurs when people eat less and exercise. The mice lived 18 percent longer than normal lab mice.
The mice were also more active than normal mice, and after eating, their brains had higher levels of a compound called superoxide dismutase, an antioxidant that protects cells from damage.
The researchers note that people who live to be 100 or more often have reduced insulin levels and their cells show better insulin sensitivity. People who exercise regularly live longer on average. Studies also show that animals on a strict diet live longer.
Exercise and lower weight keep your peripheral tissues sensitive to insulin and your body reacts by making less. This study suggests that the resulting lower levels of insulin are healthier for the brain and lead to an increased lifespan.
The findings of this study raise questions about how desirable it is to use insulin to treat type 2 diabetes.
